Isle of Palms, SC 5+ Bedroom Vacation Rentals

Welcome to Casa Margarita!**904 Ocean Blvd. Presented by Exclusive Properties Vacation Rental Agency on Isle of Palms***Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote or discounts. NOTE: Prices...

** During the summer we book Saturday to Saturday. Off-season we require a 3 nighttime minimum **--Description--As part of our Island Collection, 'Pavilion a la Plage' 4 10th Ave, is a seven bedroom, five and a half bathroom home located in the...

Bikinis and MartinisLocation: Isle of Palms, SCOverview:Welcome to Bikinis and Martinis, a impressive 5-bedroom, 5.5-bathroom new construction home located just a block from the beach on Isle of Palms. This luxury getaway offers an open-concept...

Nostos~ 6 51st Ave presented by Exclusive Properties on Isle of Palms. Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of...

** During the summer we book Saturday to Saturday. Off-season we require a 3 nighttime minimum **-- Description --'Villa del Mare' is an ocean view Mediterranean masterpiece and is located just a few steps from the beach. On the relaxing Isle of...

Vacation in style and live like royals when you book our cavernous and extravagant 609 Ocean Blvd beach home at Isle of Palms. Stay right opposite the ocean at one of the best spots in the area and spend a memorable time with your appreciated ones...

Welcome to Sand Dune. Heaven beckons from this exceptional beach home that's located only 1 block away from the sandy shores of Isle of Palms Beach. Recently remodeled in 2025, Sand Dune now features major upgrades to the kitchen and bathrooms...

Ask about our Summer 2025 discounts!! *During Summer months this home books Friday to Friday**Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote. --Description--New to our Luxury Collection...

Are you searching for an memorable luxury escape for your family? You'll be sure to find it here at Ocean Point. Overlooking both the Atlantic Ocean and the 17th Fairway of the Links Golf Course, this sprawling home offers six bedrooms and over five...

Make everlasting memories with you and your whole family on your next vacation at 808 Ocean Boulevard. 808 Ocean Boulevard is a handsome private 6 bedroom 6 bath home located oceanfront on the southern side of the Isle of Palms. Just mins. walk from...

Welcome to Sea Shell by AvantStay!Heaven beckons from this fantastic beach home that's located only 1 block away from the sandy shores of Isle of Palms Beach. After a day spent frolicking in the waves, strolling down the boardwalk, and gallivanting...

**Summer bookings are Sat. to Sat. We have a 3 nighttime min in the off-season** Description"Isle be Back" - 5 57th Avenue is one of our newest additions. It is a pretty, six bedroom, five and a half bathroom inverted floor plan home with...

Welcome to 3907 Palm Boulevard, a freshly constructed, impressive 8 bedroom oceanview home on the handsome Isle of Palms, just a short drive to the historic city of Charleston. Be among the first to experience the refined, coastal elegance...

The Rosemary House – Modern Elegance Meets Island CharmWelcome to The Rosemary House, a classy and sun-soaked getaway located just behind the gates of Wild Dunes Resort and mere steps from the pristine sands of Isle of Palms. This newly...

Welcome to 811 Ocean Boulevard on Isle of Palms! – An Enchanting Coastal RetreatStep into a realm of comfort and appeal as you discover this handsome five-bedroom, five-bathroom home located in the heart of Isle of Palms, a heaven for both...

**124 Charleston Blvd is Presented by Exclusive Properties Vacation Rental Agency on Isle of Palms**--Description--New to our luxury collection, 124 Charleston Blvd, 'Ocean's Genesis' is a rare gem. Be one of the first to experience this rare six...

Escape to this impressive 5-bedroom, 4-bath beach vacation rental at 10 Wills Way on the Isle of Palms, just 20 mins. from historic Charleston. This property is new to the rental market and features all-new furnishings, offering modern comfort with...

Incredible 5 Bedroom, 4.5 bath home with new elevated Salt Water Pool, modren furnishings and coastal décor. Executive Kitchen with Sub Zero, Wolf and Bosch appliances entirely equipped for the cooks on vacation. The dining Room seats 8 with room...