Isle of Palms, SC 5+ Bedroom Vacation Rentals
Filter 5+ Bedroom Isle of Palms Properties by: Company | Oceanfront | Pet-Friendly | or choose different a Area or Bedrooms
Areas:
- Atlantic Beach
- Avon
- Bald Head Island
- Beaufort
- Beaufort
- Buxton
- Carolina Beach
- Carova
- Charleston
- Corolla
- Duck
- Elizabeth City
- Emerald Isle
- Fripp Island
- Frisco
- Georgetown
- Grandy
- Hatteras
- Hilton Head
- Holden Beach
- Indian Beach
- Isle of Palms
- Jarvisburg
- Kill Devil Hills
- Kitty Hawk
- Kure Beach
- Manteo
- Myrtle Beach
- Nags Head
- New Bern
- Oak Island
- Ocean Isle Beach
- Ocracoke
- Pine Knoll Shores
- Point Harbor
- Poplar Branch
- Port Royal
- Powells Point
- Rodanthe
- Salvo
- Southern Shores
- Southport
- Sullivans Island
- Sunset Beach
- Wanchese
- Waves
- Wilmington
- Wrightsville Beach
No company options available.
129 rentals found
Centrally located on the breathtaking Isle of Palms just outside of historic Charleston, this handsome 5-bedroom home on 22nd Avenue is the ideal place to savor a family beach vacation! Renovated in 2021, this home provides a modern, upgraded twist...
- Isle of Palms
- 5 Bedrooms
- 3 Bathrooms
- Sleeps 12
If you’re looking for a sophisticated yet appealing beach home as a getaway from the ebbs and flows of life, 4 on 36th Avenue is where you want to be. Featuring ocean vistas from both the rooftop deck, and the pool deck, this freshly constructed...
- Isle of Palms
- 5 Bedrooms
- 6 Bathrooms
- Sleeps 12
Ask about our Spring/Summer 2026 discounts! **This home books Friday to Friday in the Summer months**--Description--Part of our luxury collection, 'Villa Las Palmas', 206 Ocean Blvd., is a seven bedroom, seven and a half bathroom oceanfront home...
- Isle of Palms
- 7 Bedrooms
- 7 Bathrooms
- Sleeps 12