Isle of Palms, SC 4+ Bedroom Vacation Rentals

28 Sand Dollar is a modern getaway located on charming Isle of Palms, South Carolina. Tucked away on a peaceful cul-de-sac this home has every detail you could want for a calming vacation. The interior was entirely remodeled in 2022.Taking a look...

White SandsLocation: Isle of Palms, South CarolinaOverview:Welcome to White Sands, a charmingly refreshed 4-bedroom, 4.5-bathroom coastal getaway on Palm Boulevard. Professionally designed with high-end finishes, this charming home offers luxury...

★ Recognized as one of our best. This home was a finalist in the 2025 AvantStay Awards, our annual celebration of top-tier stays.Welcome to 3108 Palm, your oceanfront sanctuary on the Isle of Palms. This beach villa beckons with a private...

Only 1 block from the beach! Telephone for short stays! This handsome 5 bedroom home was newly refreshed. The home sits on a huge lot and has a elegant saltwater pool, incredible screened-in back porch and breathtaking front porch. The cavernous...

One row back from the beach! This ocean view, 9 bedroom 6 and a half bath home is loaded with amenities for your family getaway. Charm and coastal style are found throughout this striking vacation home which has an in ground pool, huge yard with...

Located at #9 on 24th Avenue, this beach home features six bedrooms, six full baths, and two half baths. A beach path at the end of the block makes walking to the surf simple for the entire family, where they will find one of the best stretches of...

Introducing THE PEARL, one of our premier properties on the Isle of Palms! This roomy Charleston-style home was refreshed in early 2024 with wood floor throughout, modernized first-floor kitchen space, upgraded bathrooms, as well as unbelievable...

Gather your family together and treat them to a dream vacation at 29 on 24th Avenue on the Isle of Palms. This four-bedroom, three bath home has the amenities that will make everybody’s dreams come true. The kids will run straight to the new pool...

Welcome to Pelican, an AvantStay home!Just a block from the famed Island of Palms Beach, this gorgeous, modern getaway is the ideal spot for your next coastal hideaway. An amazing outdoor space presents a taste of heaven, where days are spent...

Escape to 38 Morgans Cove, a gorgeous 4-bedroom, 3.5-bath vacation home in the exclusive Wild Dunes Resort on the Isle of Palms, SC—just 20 mins. from historic Charleston. This coastal getaway offers the ideal blend of relaxation, adventure, and...

** During the summer we book Saturday to Saturday. Off-season we require a 3 nighttime minimum **--Description--As part of our Island Collection, 'Pavilion a la Plage' 4 10th Ave, is a seven bedroom, five and a half bathroom home located in the...

Renovated by new homeowners in January 2021, this beautiful 6 bedroom, 6.5 bathroom home is ready to welcome you for a once-in-a-lifetime beach escape. Just one block to the beach, it has all you need to make marvelous memories on the Isle of Palms...

Get ready for an appealing and fun-filled beach vacation when you select pretty accommodation for your stay. At Carroll Realty, we are excited to tell you about this roomy vacation home located right by the ocean. Walk a few steps to appreciate the...

Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in beautiful, luxury or budget friendly vacation...

This elegant 4-bedroom, 3-bathroom property has a great location across from the Intracoastal Waterway, with peek-a-boo water vistas and just a short walk from the beach. With a private pool and outdoor beach shower, this home is ideal for those...

Welcome to Heaven on Palm, a dreamlike getaway just moments from the pristine shores of Isle of Palms Beach. This one-of-a-kind escape blends casual elegance with breezy outdoor spaces, offering your group the ideal mix of comfort, connection, and...

Centrally located on the spectacular Isle of Palms just outside of historic Charleston, this charming 5-bedroom home on 22nd Avenue is the ideal place to savor a family beach vacation! Having undergone a full remodel in Spring 2021, the home...

This oceanfront, bespoke constructed 6 bedroom/8.5 bathroom home features 7,000 square feet of pure elegance. Each room was professionally designed and no expense was spared. The attention to detail includes stone floor throughout the first floor...