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Isle of Palms, SC 2+ Bedroom Vacation Rentals

340 rentals found
Modern Beach Home w/Private Pool, 3 Mast...

802 Palm BlvdIf you're ready to take a deep dive into the luxury lifestyle on Isle of Palms, SC, then this is the property for you! This marvelous 4-bedroom home has 4 bathrooms and 2 half bathrooms, and ideally sets you up to experience all the...

  • Isle of Palms
  • 4 Bedrooms
  • 5 Bathrooms
  • Sleeps 10
Golf View, Pool, Pickleball, Stocked kit...

2026 Beach Restoration UpdateThe City of Isle of Palms has approved a beach nourishment project planned for Summer-Fall 2026. Although the final schedule has not yet been announced, the work is expected to progress in sections along the shoreline...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
614 Palm Blvd. Brand New Custom Built Ho...

-614 Ocean Blvd. is Presented by Exclusive Properties Vacation Rental Agency on Isle of Palms-Ask about our Discounts!Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 11
Award-Winning Resort Amenities | Mariner...

Mariners Walk 9E by Wild Dunes3 Bedrooms | 3.5 Bathrooms | Sleeps 7 | Resort View________________________________________Located only mins. from the beach, this 1581 Sq. Ft. Mariners Walk unit features a complex pool and warm, family-friendly...

  • Isle of Palms
  • 3 Bedrooms
  • 4 Bathrooms
  • Sleeps 7
4 36th Avenue by AvantStay | ? Chef's Ki...

If you’re looking for a sophisticated yet striking beach home as a getaway from the ebbs and flows of life, 4 on 36th Avenue is where you want to be. Featuring ocean vistas from both the rooftop deck, and the pool deck, this freshly constructed...

  • Isle of Palms
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Walk to Beach + Pool Access | Beachfront...

Welcome to 313 Seascape by AvantStay, your ocean-view escape located within the gated Wild Dunes Resort on Isle of Palms. Perched on the third floor of Seascape Villas, this condo puts you steps from the beach and a world away from the everyday —...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 4
Sawyer by AvantStay | Stunning Isle Of P...

Welcome to Sawyer, an AvantStay home! Located on the elegant beachy Isle of Palms just 30 mins. away from downtown Charleston, this home is a marvelous getaway for those looking for a calming spot a ideal distance from the action. Cook up some fresh...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Ocean Club, Gated Community, Oceanfront ...

Welcome to Ocean Club Villas 1104, a 3 bedroom, 3.5 bathroom oceanfront condo, located in Wild Dunes. This well located Villa offers oceanfront living with beautiful ocean vistas, direct beach access, hot tub and pool access for the ideal vacation...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
203 Ocean Palms by AvantStay | Oceanfron...

You will think you found the ideal vacation when you discover "Oceanside Serenity" at 203 Ocean Palms on the Front Beach at the Isle of Palms. This is an oceanfront, four-bedroom, four-bath condominium with 2,000 square feet of living space...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Beachfront with OCEAN VIEWS in Wild Dune...

This refreshed two bedroom, two bathroom villa is the ideal home-away-from-home for your Isle of Palms vacation. The Shipwatch Villas are located away in the gated Wild Dunes Resort community on the Isle of Palms. The pathway to our pristine...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 5
301 Ocean Palms by AvantStay | Ocean Fro...

Why keep dreaming of a fabulous family vacation, when you can visit this splendid condominium oceanfront in the heart of Isle of Palms? “Ocean Palms” has the best of everything when it comes to a dreamy trip to the island. The enormous...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Sea Shell by AvantStay | Breezy Beachsid...

Welcome to Sea Shell by AvantStay!Heaven beckons from this marvelous beach home that's located only 1 block away from the sandy shores of Isle of Palms Beach. After a day spent frolicking in the waves, strolling down the boardwalk, and gallivanting...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
10 Sandcrab Court by AvantStay | Beautif...

Elevate your Isle of Palms hideaway when you stay at 10 Sandcrab Court! This gorgeous, modern home is located just a 4-min. walk from the beach, providing the ideal blend of comfort and convenience. Inside, you are welcomed with bright interiors and...

  • Isle of Palms
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
Modern Beach Home in Quiet Community w/G...

Are you ready to escape to the ideal beach neighborhood in Isle of Palms? Then look no further than this gorgeous 3-bedroom, 2-bathroom home located right in the heart of the island! This neighborhood enjoys proximity to local stores, eateries, a...

  • Isle of Palms
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 9
Modern Oceanview Villa in Wild Dunes Res...

Located just 50 yards from the beach in Wild Dunes Resort, this charmingly refreshed Mariners Walk condo now features a newly updated kitchen and refreshed dining space—ideal for your island hideaway. With 3 bedrooms and 3 bathrooms, it offers the...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Stay @ Will-o-Layne on Isle of Palms

2401 Palm | Will-o-LayneLocation: Isle of Palms, South Carolina Overview:Welcome to Will-o-Layne, a gorgeous and cavernous 5-bedroom, 3-bathroom family beach bungalow located directly across from the ocean on the Isle of Palms. This appealing home...

  • Isle of Palms
  • 5 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Oasis w/ Private Pool, Pets considered, ...

Welcome to your hideaway getaway at The Pink House! 5 Bedroom, 3 Bathroom home with all new refreshed bathrooms as of 2023, a 50ft long private pool, and less than a 2 min. walk to the beach. The pool has two 6 in wading areas that is great for...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Award-Winning Resort Amenities | Yacht H...

Yacht Harbor Villa 409 by Wild Dunes3 Bedrooms | 2 Bathrooms | Sleeps 8 | Resort View________________________________________Featuring captivating marina scenery, this 1400 Sq. Ft. Yacht Harbor Villas Condo features a complex pool and screened...

  • Isle of Palms
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 8