Isle of Palms, SC 5+ Bedroom Vacation Rentals

Welcome to 306 Charleston Roosevelt Retreat by AvantStay, a rare Isle of Palms gem where coastal ease meets rich American history. Constructed in 1958 by Nicholas G. Roosevelt—a cousin of Franklin D. Roosevelt and a direct descendant of the...

Welcome to Casa Margarita!**904 Ocean Blvd. Presented by Exclusive Properties Vacation Rental Agency on Isle of Palms***Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote or discounts. NOTE: Prices...

Welcome to Sand Dune. Heaven beckons from this fantastic beach home that's located only 1 block away from the sandy shores of Isle of Palms Beach. Recently modernized in 2025, Sand Dune now features major upgrades to the kitchen and bathrooms...

**Ask about our current discounts for Spring/Summer 2026!Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We...

Will-o-LayneLocation: Isle of Palms, South CarolinaOverview:Welcome to Will-o-Layne, a handsome and roomy 5-bedroom, 3-bathroom family beach bungalow located directly across from the ocean on the Isle of Palms. This beautiful home offers the ideal...

Welcome to your dream coastal getaway! Located just steps away from the sandy shores, this freshly modernized five-bedroom, five-bathroom home is a masterpiece of luxury and comfort. The exterior is adorned with lush landscaping, creating a serene...

Your Isle of Palms Heaven Awaits!✨Property Highlights- Private Pool & Putting Green- Ocean Vistas from Second Level- Modern Beachy Decor- Steps to Public Beach Access- $250 Beach Gear Credit with 3-14 nighttime stays!Please note that every...

The Rosemary House – Modern Elegance Meets Island CharmWelcome to The Rosemary House, a classy and sun-soaked getaway located just behind the gates of Wild Dunes Resort and mere steps from the pristine sands of Isle of Palms. This freshly...

Coming Soon - New Pictures coming May 30!Modern, Top-of-Line Beach Home Across from Beach Access - Totally Renovated with Private Pool All new Pictures coming in late May!Property Highlights- Private Pool - can be heated for additional cost- Ocean...

Step into unparalleled coastal luxury at this freshly constructed, professionally designed oceanfront 5-bedroom home—one of Isle of Palms' premier vacation units. Sandcastle, 2704 Palm Blvd., has every detail crafted for high-end living, from the...

Tucked into the peaceful north end of Isle of Palms, 3602 Cameron is the kind of beach home that makes you slow down the second you walk in. The ocean is essentially across the street — Beach Access 34A sits just steps from the front door, so...

** During the summer we book Friday to Friday. Off-season we require a 3 nighttime minimum **--Description--'Coastal Manor' is a brand new bespoke constructed home located on Palm Blvd. right across from the ocean with a convenient beach access just...

*New Bedroom Photos Coming Soon!*Are you searching for an memorable luxury escape for your family? You'll be sure to find it here at Ocean Point. Overlooking both the Atlantic Ocean and the 17th Fairway of the Links Golf Course, this sprawling home...

Fishers Alley 2 by Wild Dunes5 Bedrooms | 5.5 Bathrooms | Sleeps 10 | ________________________________________Welcome to Fishers Alley 2, a striking getaway on Isle of Palms’ exclusive Wild Dunes Resort. Just a block and a half from the beach...

Welcome to 3 47th Avenue, where striking architecture meets modern design. This roomy getaway invites you to indulge in the ideal blend of luxury and comfort.Marvel at the unique private pool, boasting an in-water sitting area for unparalleled...

Sensational ocean vistas! Ready for a beach hideaway with warm sunshine, ocean breezes, sandy toes, and exhilarating dips in your own private saltwater pool? Gone Coastal is a attractively furnished 6 bedroom beach-side getaway, with only a fast...

Snowbirds Welcome!!Winter Escape to IOP.....Property Description Discover the pinnacle of luxury beach living at this exquisitely designed beach home, located in the heart of Isle of Palms, South Carolina. This impeccable getaway blends coastal...

Make everlasting memories with you and your whole family on your next vacation at 808 Ocean Boulevard. 808 Ocean Boulevard is a striking private 6 bedroom 6 bath home located oceanfront on the southern side of the Isle of Palms. Just mins. walk from...